Reagent for determining contact allergy

专利摘要:
Novel means and method for carrying out occlusive epicutaneous tests (patch tests). This type of test is employed for detecting contact allergy to some specific substance (allergen) or for testing allergenic and/or irritant properties of a substance. The invention is characterized in that the test substance is incorporated in a film.
公开号:SU1695821A3
申请号:SU864027623
申请日:1986-05-30
公开日:1991-11-30
发明作者:Ингемар Фишер Торкель
申请人:Торкель Ингемар Фишер (SE)；
IPC主号:

专利说明:

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The invention relates to medicine, in particular to reagents for the determination of contact allergies.
The purpose of the invention is to increase the sensitivity of the reagent.
Contact allergy testing reagent consists of a strip of adhesive material containing at least one flap (mostly twelve), covered with a carrier film with an allergen substance included in it. The strip may contain a set of flaps with various allergenic substances. The strip is covered with a protective sheet, which is removed before use.
As a carrier, film-forming polysaccharides are used, for example, alkyl or oxyl alkyl cellulose.
Partially methylated cellulose is a good carrier, as it has film-forming properties, good hydrophilic-hydrophobic
balance, lack of irritation of human skin.
The thickness of the carrier film is not more than 0.25 mm.
Example 1. Metocel (methylcellulose with a methylation degree of 27-31%) is stirred in hot water and a gel is obtained (3% by weight). Metal salts (crystalline or in the form of solutions in water) are introduced into the gel, water is added to a concentration of Metocell of 2.4 wt.%. The gel is then thoroughly mixed until the salts are homogeneously dispersed. To remove air bubbles, the gel is centrifuged, then applied to the flaps.
The concentration of the metal salt in the gel is mol / L:
NICI20,000049 - 0.008
NIS040,000049 - 0 2
CoCl20,0031-0.2
K2SG20 0.0031-0.1
ABOUT
about ate with

cm
sodium odecyl sulfate, wt%: 0.5; 1.0; 2.0; 4.0.
The gel, containing a certain allergen, is sprayed with a layer of about 0.1 mm at a certain concentration onto a film carrier impregnated with ethyl alcohol, the gel layer is dried at room temperature (a film with a thickness of 0.01 mm is obtained), cut into flaps 0.2- 0.5 cm2 and applied to the adhesive strip. The 1 cm size flaps containing the metal salts of Example 1 are placed on the upper back of the patient, secured with adhesive tape and left for 48 and 72 hours.
Metocel films may contain neo-mycin sulfate, ethylene diamine hydrochloride, Peruvian balsam,
Example 2. Various allergenic substances are introduced into the Clucel gel from hydroxypropyl cellulose.
As a solvent, different concentrations of ethyl alcohol are used depending on the type of allergen used.
The concentrations of substances in the resulting gel are presented in the table.
The resulting gels are applied to film carriers and dried. The film carrier is a polyester film hydrophilicized by corona treatment, which improves the adhesion of the film.
Nickel sulfate, potassium dichromate, Peruvian balsam, ethylene diamine hydrochloride, cobalt chloride, tiouaram mixture, kain mixture, epoxy resins are also used as allergenic substances in the Clucel film.
Reagents for determining contact
Allergies in accordance with the invention have a higher sensitivity, improved dosage of allergenic substances, and are stable during storage.
Flaps containing various allergenic substances can be placed on one adhesive sheet, while the patient can be examined simultaneously for many allergens and / or for different amounts of the same allergen.
unit area.

权利要求:
Claims (1)
[1]
DETAILED DESCRIPTION OF THE INVENTION Reagent for determining contact allergy containing at least one flap with a polymeric carrier and a contact allergen introduced into it, characterized in that, in order to increase the sensitivity of the reagent, the flap dimensions are 0.2-0.5 cm The thickness of the carrier film is not more than 0.25 mm, and a hydrophilic film-forming polysaccharide or its derivatives is used as a carrier.

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---

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---

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---

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---

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引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

DE8320480U1|1983-11-17|Pirilä, Veikko Paavo, Prof.-Dr., 04300 Hyrylä, Paijala|Blade type test device|

---

US3507269A|1965-04-26|1970-04-21|Homer H Berry|Clinical diagnostic device for halitosis|

---

US3419006A|1966-08-08|1968-12-31|Union Carbide Corp|Novel dressing and use thereof|

---

SE318060B|1966-08-11|1969-12-01|G Fregert|

---

US3552929A|1968-01-23|1971-01-05|Minnesota Mining & Mfg|Diagnosis means|

---

US3797494A|1969-04-01|1974-03-19|Alza Corp|Bandage for the administration of drug by controlled metering through microporous materials|

---

US3703890A|1970-08-10|1972-11-28|Milton A Saunders Jr|Skin patch test device|

---

US3996934A|1971-08-09|1976-12-14|Alza Corporation|Medical bandage|

---

US3742951B1|1971-08-09|1982-11-23|

---

FI52268C|1973-03-15|1977-08-10|Veikko Paavo Pirilae|Cover for skin test.|

---

US3900027A|1974-01-02|1975-08-19|Pall Corp|Process for preparing integral absorbent pad bandages and product|

---

US3894531A|1974-04-12|1975-07-15|Jr Milton A Saunders|Skin patch test device with peelable label|

---

US4304591A|1978-01-25|1981-12-08|Ciba-Geigy Corporation|Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides|

---

US4675009A|1977-11-07|1987-06-23|Lec Tec Corporation|Drug dispensing device for transdermal delivery of medicaments|

---

US4014334A|1976-02-02|1977-03-29|Alza Corporation|Laminated osmotic system for dispensing beneficial agent|

---

FR2375861B1|1976-12-31|1981-06-26|Merieux Inst|

---

US4158359A|1977-01-24|1979-06-19|Kanebo Limited|Device for testing influence of medicinal or cosmetic substance on skin|

---

US4083974A|1977-03-07|1978-04-11|The Upjohn Company|Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether|

---

US4390027A|1981-03-19|1983-06-28|Alani Safwat D|Application unit for epicutaneous testing or treatment|

---

US4472507A|1981-06-04|1984-09-18|Pluim Jr Arthur W|Method for detecting exposure to poison ivy and the like|

---

US4450844A|1981-11-23|1984-05-29|Hill Top Research, Inc.|Patch system for use on the skin|

---

US4444193A|1982-01-11|1984-04-24|Medtronic, Inc.|Fluid absorbent quantitative test device|

---

DK8601218A|1984-07-18|1986-03-17|

---

JPS64613A|1987-06-23|1989-01-05|Mitsubishi Rayon Co Ltd|Manufacture of conductive high polymer material|

---

JPH112323A|1997-06-10|1999-01-06|Hino Motors Ltd|Piston ring|SE452251B|1986-06-26|1987-11-23|Pharmacia Ab|TEST STRAP INTENDED TO BE USED IN EXCLUSIVE EPIC TEST TO PAVISA CONTACT ALERGY|

---

SE458339B|1987-05-25|1989-03-20|Pharmacia Ab|TEST REMEMBER TO PROVIDE CONTACT ALLERGY|

---

JP2520262B2|1987-08-21|1996-07-31|春幸 川原|Patch test material|

---

SE8802403D0|1988-06-28|1988-06-28|Pharmacia Ab|MUST BE USED IN EXCLUSIVE EPIC TESTING TO PAVISA CONTACT ALERGY|

---

GB2239708A|1989-08-24|1991-07-10|Sam Shuster|Allergy patch testing|

---

AU5575294A|1992-12-07|1994-07-04|Hisamitsu Pharmaceutical Co., Inc.|Plaster for testing and method of testing|

---

DE4242040A1|1992-12-12|1994-06-16|Hauser Willy E|Coated carrier for the diagnosis and therapy of diseases as well as use of the carrier|

---

ES2106688B1|1996-03-04|1998-05-16|Subiza Garrido Lestache Javier|NEW APPLICABLE LAMINAR SUPPORT FOR THE REALIZATION OF EPICUTANEOUS TESTS.|

---

US5980898A|1996-11-14|1999-11-09|The United States Of America As Represented By The U.S. Army Medical Research & Material Command|Adjuvant for transcutaneous immunization|

---

JP4476488B2|1998-08-18|2010-06-09|ダームテックインターナショナル|Methods for detecting biological factors in the epidermis|

---

US8512718B2|2000-07-03|2013-08-20|Foamix Ltd.|Pharmaceutical composition for topical application|

---

US7635488B2|2001-03-13|2009-12-22|Dbv Technologies|Patches and uses thereof|

---

FR2822049B1|2001-03-13|2003-08-01|Dbv Medica 1|PATCH INTENDED IN PARTICULAR TO DETECT THE STATE OF SENSITIZATION OF A SUBJECT TO AN ALLERGEN, METHOD OF MANUFACTURING AND USE|

---

WO2003001985A2|2001-06-28|2003-01-09|Dermtech International|Method for detection of melanoma|

---

NZ540166A|2002-10-25|2007-06-29|Foamix Ltd|Cosmetic and pharmaceutical foam|

---

US9265725B2|2002-10-25|2016-02-23|Foamix Pharmaceuticals Ltd.|Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof|

---

US8486376B2|2002-10-25|2013-07-16|Foamix Ltd.|Moisturizing foam containing lanolin|

---

US9668972B2|2002-10-25|2017-06-06|Foamix Pharmaceuticals Ltd.|Nonsteroidal immunomodulating kit and composition and uses thereof|

---

US7700076B2|2002-10-25|2010-04-20|Foamix, Ltd.|Penetrating pharmaceutical foam|

---

US8119109B2|2002-10-25|2012-02-21|Foamix Ltd.|Foamable compositions, kits and methods for hyperhidrosis|

---

US8119150B2|2002-10-25|2012-02-21|Foamix Ltd.|Non-flammable insecticide composition and uses thereof|

---

US10117812B2|2002-10-25|2018-11-06|Foamix Pharmaceuticals Ltd.|Foamable composition combining a polar solvent and a hydrophobic carrier|

---

US9211259B2|2002-11-29|2015-12-15|Foamix Pharmaceuticals Ltd.|Antibiotic kit and composition and uses thereof|

---

US20080138296A1|2002-10-25|2008-06-12|Foamix Ltd.|Foam prepared fromnanoemulsions and uses|

---

US8900554B2|2002-10-25|2014-12-02|Foamix Pharmaceuticals Ltd.|Foamable composition and uses thereof|

---

IL152486D0|2002-10-25|2003-05-29|Meir Eini|Alcohol-free cosmetic and pharmaceutical foam carrier|

---

US7575739B2|2003-04-28|2009-08-18|Foamix Ltd.|Foamable iodine composition|

---

US7704518B2|2003-08-04|2010-04-27|Foamix, Ltd.|Foamable vehicle and pharmaceutical compositions thereof|

---

US8795693B2|2003-08-04|2014-08-05|Foamix Ltd.|Compositions with modulating agents|

---

US8486374B2|2003-08-04|2013-07-16|Foamix Ltd.|Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses|

---

US7820145B2|2003-08-04|2010-10-26|Foamix Ltd.|Oleaginous pharmaceutical and cosmetic foam|

---

US20060147341A1|2004-12-30|2006-07-06|Jahngen Edwin G|Article and method for detecting skin irritants|

---

CA2630840A1|2005-11-23|2007-05-31|Universitaet Zuerich|Allergy treatment by epicutaneous allergen administration|

---

US20080260655A1|2006-11-14|2008-10-23|Dov Tamarkin|Substantially non-aqueous foamable petrolatum basedpharmaceutical and cosmetic compositions and their uses|

---

AU2008247502A1|2007-05-04|2008-11-13|Dermtech International|Diagnosis of melanoma by nucleic acid analysis|

---

US8636982B2|2007-08-07|2014-01-28|Foamix Ltd.|Wax foamable vehicle and pharmaceutical compositions thereof|

---

FR2921562B1|2007-10-01|2012-06-15|Dbv Tech|ADHESIVE DEVICE FOR SKIN APPLICATION|

---

US9439857B2|2007-11-30|2016-09-13|Foamix Pharmaceuticals Ltd.|Foam containing benzoyl peroxide|

---

FR2924350B1|2007-12-03|2010-08-13|Dbv Tech|METHOD AND COMPOSITIONS FOR SKIN VACCINATION|

---

FR2924349B1|2007-12-03|2010-01-01|Dbv Tech|ALLERGEN DISENSIBILITY METHOD|

---

US8518376B2|2007-12-07|2013-08-27|Foamix Ltd.|Oil-based foamable carriers and formulations|

---

WO2009090495A2|2007-12-07|2009-07-23|Foamix Ltd.|Oil and liquid silicone foamable carriers and formulations|

---

EP2242476A2|2008-01-14|2010-10-27|Foamix Ltd.|Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses|

---

FR2926466B1|2008-01-23|2010-11-12|Dbv Tech|METHOD FOR MANUFACTURING PATCHES BY ELECTROSPRAY|

---

US20110160080A1|2008-05-14|2011-06-30|Chang Sherman H|Diagnosis of Melanoma and Solar Lentigo by Nucleic Acid Analysis|

---

EP2331707A4|2008-08-28|2012-06-06|Dermtech Int|Determining age ranges of skin samples|

---

US20120087872A1|2009-04-28|2012-04-12|Foamix Ltd.|Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof|

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CA2769677A1|2009-07-29|2011-02-03|Foamix Ltd.|Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses|

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US8174881B2|2009-11-24|2012-05-08|Micron Technology, Inc.|Techniques for reducing disturbance in a semiconductor device|

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WO2013001007A1|2011-06-29|2013-01-03|Hds Limited|An improved micropatch for assessing chemical contact allergy|

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US20130108553A1|2011-11-02|2013-05-02|Curtis P. Hamann|Metal Mixes For Use In Epicutaneous Patch Test|

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CN107951468B|2017-11-20|2020-08-11|珠海伊斯佳科技股份有限公司|Compound film composition for acquiring skin physiological state and preparation and application thereof|

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US10492718B2|2018-04-09|2019-12-03|Mark R. Drzala|Apparatus for assessing skin reactivity to a material|

法律状态:

优先权:

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申请号 | 申请日 | 专利标题

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SE8404895A|SE8404895L|1984-10-01|1984-10-01|MEANS OF A SENSITIVITY TEST|

---